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God does not exist if Big Bang cosmology, or some relevantly similar theory, is true. If this cosmology is true, our universe exists without cause and without explanation. There are numerous possible universes, and there is possibly no universe at all, and there is no reason why this one is actual rather than some other one or none at all. Now the theistically alleged human need for a reason for existence, and other alleged needs, are unsatisfied. But I suggest that humans do or can possess a deeper level of experience than such anthropocentric despairs. We can forget about ourselves for a moment and open ourselves up to the startling impingement of reality itself. We can let ourselves become profoundly astonished by the fact that this universe exists at all.

A central dilemma in contemporary metaphysics is to find a place for certain anthropocentric subject-matters — for instance, semantic, moral, and psychological — in a world as conceived by modern naturalism: a stance which inflates the concepts and categories deployed by (finished) physical science into a metaphysics of the kind of thing the real world essentially and exhaustively is. On one horn, if we embrace this naturalism, it seems we are committed either to reductionism: that is, to a construal of the reference of, for example, semantic, moral and psychological vocabulary as somehow being within the physical domain — or to disputing that the discourses in question involve reference to what is real at all. On the other horn, if we reject this naturalism, then we accept that there is more to the world than can be embraced within a physicalist ontology — and so take on a commitment, it can seem, to a kind of eerie supernaturalism.

One could retreat to a mere methodological naturalism and say that scientific method is our only hope as human beings. Whether or not we can adequately specify naturalism or know it to be true, one might say, the "scientific method" must be exclusively followed for human well-being. Naturalism would then be a humane proposal, not a philosophical claim. The proposal would be to assume in our inquiries that only the physical (or the empirical) exists and to see if inquiry based upon that assumption is not more successful in promoting human ends than any other type of inquiry.

There is no consensus yet about the details of the scientific image of persons. But there is broad agreement about how we must construct this detailed picture. First, we will need to demythologize persons by rooting out certain unfounded ideas from the perennial philosophy. Letting go of the belief in souls is a minimal requirement. In fact, desouling is the primary operation of the scientific image. "First surgery," we might call it. There are no such things as souls, or nonphysical minds. If such things did exist, as perennial philosophy conceives them, science would be unable to explain persons. But there aren't, so it can. Second, we will need to think of persons as part of nature — as natural creatures completely obedient and responsive to natural law. The traditional religious view positions humans on the Great Chain of Being between animals on one side and angels and God on the other. This set of beliefs needs to be replaced. There are no angels, nor gods, and there is nothing — at least, no higher beings — for humans to be in-between. Humans don't possess some animal parts or instincts. We are animals. A complex and unusual animal, but at the end of the day, another animal.

Accusations of barren desolation, of promoting an arid and joyless message, are frequently flung at science in general ... But such very proper purging of saccharine false purpose; such laudable tough-mindedness in the debunking of cosmic sentimentality must not be confused with a loss of personal hope. Presumably there is indeed no purpose in the ultimate fate of the cosmos, but do any of us really tie our life's hopes to the ultimate fate of the cosmos anyway? Of course we don't; not if we're sane. Our lives are ruled by all sorts of closer, warmer, human ambitions and perceptions. To accuse science of robbing life of the warmth that makes it worth living is so preposterously mistaken, so diametrically opposite to my own feelings and those of most working scientists, I am almost driven to the despair of which I am wrongly suspected. ... The feeling of awed wonder that science can give is us one of the highest experiences of which the human psyche is capable. It is a deep aesthetic passion to rank with the finest that music and poetry can deliver. It is truly one of the things that makes life worth living and it does so, if anything, more effectively if it convinces us that the time we have for living it is finite.

[T]he logic of materialist reductionism implies that science itself is the product of unreasoning material causes. No wonder the Age of Reason ends with the age of postmodernist relativism! And yet we still see the reductionists complacently describing religious belief either as a meme or as the product of a "God module" in the brain without realizing that they are sawing off the limb on which they themselves are sitting. If unthinking matter causes the thoughts the materialists don't like, then what causes the thoughts they do like?

By any realistic definition naturalism is a religion, and an extremely dogmatic one. It rests on a basic conviction about ultimate reality that is held by a kind of faith, and it incorporates its own definitions of "knowledge" and "reason." It says that knowledge comes ultimately from our senses and that the more complex forms of knowledge come from scientific investigation. By naturalistic definition there can be no such thing as knowledge of the supernatural. Statements about God are either nonrational (if frankly presented as mere subjective belief) or irrational (if they purport to make objective factual claims).

The religious hypothesis of mind-body dualism has been in trouble with evolutionary biology, and with several other sciences as well, for more than a century. It didn't need any special input from artificial intelligence or neuroscience to make it scientifically implausible. I bring it up here only because it is a clear example of a popular and important belief currently under siege by modern information. And because its example may be repeated. The fact is, there is a much more intriguing area of current conceptual commitment, one more likely to be affected by emerging cognitive theory in particular. It lies even closer to home and is even more widespread, if that is possible, than mind-body dualism. It is our current self-conception: our shared portrait of ourselves as self-conscious creatures with beliefs, desires, emotions, and the power of reason.

Your brain is far too complex and mercurial for its behavior to be predicted in any but the broadest outlines or for any but the shortest distances in the future. Faced with the extraordinary dynamical features of a functioning brain, no device constructible in this universe could ever predict your behavior, or your thoughts, with anything more than merely statistical success. ¶ So one need not fear being reduced to a clanking robot or an empty machine. Quite to the contrary, we are now in a position to explain how our vivid sensory experience arises in the sensory cortex of our brains: how the smell of baking bread, the sound of an oboe, the taste of a peach, and the color of a sunrise are embodied in a vast chorus of neural activity. We now have the resources to explain how the motor cortex, the cerebellum, and the spinal cord conduct an orchestra of muscles to perform the cheetah's dash, the falcon's strike, or the ballerina's dying swan. ... On this matter of conceptual development there is especial cause for wonder. For the human brain, with a volume of roughly a quart, encompasses a space of conceptual and cognitive possibilities that is larger, by one measure at least, than the entire astronomical universe. It has this striking feature because it exploits the combinatorics of its 100 billion neurons and their 100 trillion synaptic connections with each other.

The supposedly immaterial soul, we now know, can be bisected with a knife, altered by chemicals, started or stopped by electricity, and extinguished by a sharp blow or by insufficent oxygen.

...the Central Idea of the consilience worldview is that all tangible phenomena, from the birth of the stars to the workings of social institutions, are based on material processes that are ultimately reducible, however long and torturous the sequences, to the laws of physics.