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George Gaylord Simpson on the First Cause

There is neither need nor excuse for postulation of non-material intervention in the origin of life, the rise of man, or any other part of the long history of the material cosmos. Yet the origin of that cosmos and the causal principles of its history remain unexplained and inaccessible to science. Here is hidden the First Cause sought by theology and philosophy. The First Cause is not known and I suspect it will never be known to living man. We may, if we are so inclined, worship it in our own ways, but we certainly do not comprehend it.