John Searle on How We Fit In a Universe of ParticlesFreedom and Neurobiology: Reflections on Free Will, Language, and Political Power (Columbia University Press: August 13, 2013), p. 22.
There is exactly one overriding question in contemporary philosophy… How do we fit in? … We now have a reasonably well-established conception of the basic structure of the universe. We have plausible theories about the origin of the universe in the Big Bang, and we understand quite a number of things about the structure of the universe in atomic physics and chemistry. We have even come to understand the nature of the chemical bond. We know a fair amount about our own development on this little Earth during the past five billion years of evolution. We understand that the universe consists entirely of particles (or whatever entities the ultimately true physics arrives at), and these exist in fields of force and are typically organized into systems. On our Earth, carbon-based systems made of molecules that also contain a lot of hydrogen, nitrogen and oxygen have provided the substrate of human, animal and plant evolution. … The most important set of basic facts, for our present purposes, are given in the atomic theory of matter and the evolutionary theory of biology. … It is not at all easy to reconcile the basic facts with … a conception of ourselves as conscious, intentionalistic, rational, social, institutional, political, speech-act performing, ethical and free will possessing agents. Now, the question is, How can we square this self-conception of ourselves as mindful, meaning-creating, free, rational, etc., agents with a universe that consists entirely of mindless, meaningless, unfree, non rational, brute physical particles?